LY2584702 BASE
LY-2584702 (free base)
CAS: 1082949-67-4
Molecular Formula: C21H19F4N7
LY2584702 BASE - Names and Identifiers
LY2584702 BASE - Physico-chemical Properties
| Molecular Formula | C21H19F4N7 |
| Molar Mass | 445.42 |
| Solubility | DMSO: ≥ 4.5 mg/mL |
| Appearance | solid |
| Color | Yellow |
| Storage Condition | RT (des.) |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20° for up to 3 months. |
| Use | LY-2584702 free base is an ATP competitive selective p70S6K inhibitor with an IC50 of 4 nM. The IC50 of LY-2584702 inhibition of S6K1 is 2 nM. |
| In vitro study | In HCT116 colon cancer cells, LY2584702 inhibited phosphorylation of S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μm. When LY258470 is combined with the EGRF inhibitor erlotinib or the mTOR inhibitor everolimus, there is a significant synergistic effect. |
| In vivo study | LY2584702 (12.5 mg/kg BID) showed significant anti-tumor effects in U87MG glioblastoma and HCT116 colon cancer xenograft models. |
LY2584702 BASE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.245 ml | 11.225 ml | 22.451 ml |
| 5 mM | 0.449 ml | 2.245 ml | 4.49 ml |
| 10 mM | 0.225 ml | 1.123 ml | 2.245 ml |
| 5 mM | 0.045 ml | 0.225 ml | 0.449 ml |
Last Update：2024-01-02 23:10:35
Supplier List
Spot supply
Product Name: LY-2584702 (free base) Visit Supplier Webpage Request for quotationCAS: 1082949-67-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: LY-2584702 (free base) Visit Supplier Webpage Request for quotationCAS: 1082949-67-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History